The current issue of JAMA (2024)

Audio Highlights

free access online only has audio

JAMA. 2024;332(2):e2318339. doi:10.1001/jama.2023.18339

• Audio: EEG-Guided Anesthesia and Delirium, Integrating Clinical Trials With Clinical Practice, Depression Review, and more

Electroencephalography-Guided Anesthesia and Delirium in Older Adults After Cardiac Surgery: The ENGAGES-Canada Randomized Clinical Trial

AlainDeschamps,MD, PhD; ArbiBen Abdallah,PhD; EricJacobsohn,MD, ChB; et al.

JAMA. 2024;332(2):112-123. doi:10.1001/jama.2024.8144

This randomized clinical trial examines whether electroencephalogram -guided anesthesia decreases the incidence of delirium after cardiac surgery among adults 60 years or older.

• Editorial

  Anesthesia Dose and Delirium—A Picture Coming Into Focus

  MilesBerger,MD, PhD; Mark D.Neuman,MD, MSc

  JAMA

Association Between Cost Sharing and Naloxone Prescription Dispensing

Kao-PingChua,MD, PhD; Rena M.Conti,PhD; PoojaLagisetty,MD; et al.

JAMA. 2024;332(2):124-132. doi:10.1001/jama.2024.8378

This study evaluates the association between cost sharing and naloxone prescription abandonment (nondispensing of naloxone prescriptions) in commercial insurance and Medicare plans.

• Editorial

  Costs and Essential Drug Access—The Case of Naloxone

  LeoBeletsky,JD, MPH; Max Jordan NguemeniTiako,MD, MS

  JAMA

Mortality and Morbidity in Adults With Rheumatic Heart Disease

GanesanKarthikeyan,DM; MpikoNtsekhe,PhD; ShofiqulIslam,PhD; et al.

has active quiz

JAMA. 2024;332(2):133-140. doi:10.1001/jama.2024.8258

This prospective observational study investigates mortality rates and predictive risk factors for rheumatic heart disease in 24 endemic low- and middle-income countries and evaluates interventions like corrective valve surgery and valvuloplasty.

• Editorial

  Rheumatic Heart Disease—A Neglected Tragedy in Young Patients

  KumarNarayanan,MD; EloiMarijon,MD, PhD

  JAMA Cardiol

Trends in Naloxone Dispensing From Retail Pharmacies in the US

S. MichaelaRikard,PhD; Andrea E.Strahan,PhD; Lyna Z.Schieber,MD, DPhil; et al.

JAMA. 2024;332(2):165-167. doi:10.1001/jama.2024.8323

This cross-sectional study examines trends in naloxone dispensing by US retail pharmacies from 2019 to 2023, including prescriber specialty and product brand.

Trends in Preeclampsia Risk Factors in the US From 2010 to 2021

Mariam K.Ayyash,MD, MSCR; RodneyMcLarenJr,MD; MajidShaman,MD; et al.

JAMA. 2024;332(2):167-169. doi:10.1001/jama.2024.8931

This population-based retrospective study uses data from the National Vital Statistics System to evaluate trends in risk factors for preeclampsia in the US between 2010 and 2021.

Integrating Clinical Trials and Practice

The Integration of Clinical Trials With the Practice of Medicine: Repairing a House Divided

Derek C.Angus,MD, MPH; Alison J.Huang,MD, MAS; Roger J.Lewis,MD, PhD; et al.

has active quiz has audio

JAMA. 2024;332(2):153-162. doi:10.1001/jama.2024.4088

This Special Communication discusses the need for better integration of clinical trials and health care delivery enterprises.

• Audio: Integrating Clinical Trials With the Practice of Medicine

• Editorial

  Introducing the JAMA Summit

  KirstenBibbins-Domingo,PhD, MD, MAS; Derek C.Angus,MD, MPH; HannahPark; Roger J.Lewis,MD, PhD; RohanKhera,MD, MS; JenniferZeis; AnnetteFlanagin,RN, MA; GregoryCurfman,MD

  JAMA

• Editor's Note

  Integrating Clinical Trials and Practice: A New JAMA Series and Call for Papers

  GregoryCurfman,MD

  JAMA

Health and the 2024 US Election

Early Pregnancy Loss in an Era of “Wrongful Embryonic Death”

Allen J.Wilcox,MD, PhD; Lisa C.Ikemoto,JD, LLM

JAMA. 2024;332(2):99-100. doi:10.1001/jama.2024.7403

This Viewpoint examines the possible legal consequences of pregnancy loss following the Alabama Supreme Court’s decision to extend personhood to laboratory-conceived embryos.

Upholding Standards for Qualified Bilingual Staff

AdaugoAmobi,MD, MPH

JAMA. 2024;332(2):101-102. doi:10.1001/jama.2024.8896

This Viewpoint discusses ways to ensure the proficiency of bilingual communication among health care staff in patient-clinician encounters, such as language testing and use of professional interpreters.

Integrating Clinical Trials and Practice

Why Should the FDA Focus on Pragmatic Clinical Research?

Ali B.Abbasi,MD; Lesley H.Curtis,PhD; Robert M.Califf,MD

JAMA. 2024;332(2):103-104. doi:10.1001/jama.2024.6227

This Viewpoint from the FDA discusses how pragmatic clinical research—assessment that uses real-world data, often in combination with research data, after initial marketing approval—can help in evaluation of new technologies, benefit research sites in underresourced settings, and better inform regulatory decisions and clinical practice.

• Editor's Note

  Integrating Clinical Trials and Practice: A New JAMA Series and Call for Papers

  GregoryCurfman,MD

  JAMA

The Weight of a Differential

Maren E.Olson,MD, MPH, MEd

JAMA. 2024;332(2):105-106. doi:10.1001/jama.2024.8766

In this narrative medicine essay, when a physician’s mother begins experiencing postmenopausal bleeding, the author wonders what it would be like to hear someone’s signs and symptoms and not automatically begin to build a differential.

Anesthesia Dose and Delirium—A Picture Coming Into Focus

MilesBerger,MD, PhD; Mark D.Neuman,MD, MSc

JAMA. 2024;332(2):107-108. doi:10.1001/jama.2023.26819

Costs and Essential Drug Access—The Case of Naloxone

LeoBeletsky,JD, MPH; Max Jordan NguemeniTiako,MD, MS

JAMA. 2024;332(2):109-110. doi:10.1001/jama.2024.7012

Management of Depression in Adults: A Review

Gregory E.Simon,MD, MPH; NathalieMoise,MD, MS; David C.Mohr,PhD

has active quiz has audio

JAMA. 2024;332(2):141-152. doi:10.1001/jama.2024.5756

This narrative review uses data from network meta-analyses and systematic reviews to explore the prevalence, diagnosis, and treatment of major depression in US adults, including specific forms of psychotherapy and more than 20 antidepressant medications.

• Audio: Managing Depression in Adults

Test-Negative Study Designs for Evaluating Vaccine Effectiveness

NatalieDean,PhD; Avnika B.Amin,PhD

has active quiz

JAMA. 2024;332(2):163-164. doi:10.1001/jama.2024.5633

This JAMA Guide to Statistics and Methods article explains the test-negative study design, an observational study design routinely used to estimate vaccine effectiveness, and examines its use in a study that estimated the performance of messenger RNA boosters against the Omicron variant.

Integrating Clinical Trials and Practice

Integrating Clinical Trials and Practice: A New JAMA Series and Call for Papers

GregoryCurfman,MD

free access

JAMA. 2024;332(2):111. doi:10.1001/jama.2024.10266

Poetry and Seeing the Sacred in Medicine

RafaelCampo,MD, MA

JAMA. 2024;332(2):174. doi:10.1001/jama.2024.7221

Syphilis Has Surged for Reasons That Go Beyond the Pathogen That Causes It

RitaRubin,MA

has audio

JAMA. 2024;332(2):92-95. doi:10.1001/jama.2024.2978

This Medical News story discusses the multiple factors contributing to the resurgence of syphilis in the US.

• Audio: June 2024 Medical News Summary

AAP Changes Its Breastfeeding Policy for People With HIV in US

EmilyHarris

JAMA. 2024;332(2):96. doi:10.1001/jama.2024.10335

Counting Minutes, Steps Linked With Similar Mortality Reduction

EmilyHarris

JAMA. 2024;332(2):96. doi:10.1001/jama.2024.10336

• Editor's Note

  Tracking Physical Activity One Step at a Time

  Cary P.Gross,MD; Raegan W.Durant,MD, MPH

  JAMA Intern Med

Rare Inherited Tumor Syndrome Tied to Nail Condition

EmilyHarris

JAMA. 2024;332(2):96. doi:10.1001/jama.2024.10337

Progestogen May Lower Risk for More Surgery for Endometriosis Pain

EmilyHarris

JAMA. 2024;332(2):96. doi:10.1001/jama.2024.10338

Having Peers With Mental Disorders Might Increase Classmates’ Risk

EmilyHarris

JAMA. 2024;332(2):96-97. doi:10.1001/jama.2024.10339

Fish Oil Pills Associated With Increased Risk of Heart Problems in Healthy People

EmilyHarris

JAMA. 2024;332(2):97. doi:10.1001/jama.2024.10340

Cognitive Impairment Underestimated Among American Indian People

EmilyHarris

JAMA. 2024;332(2):97. doi:10.1001/jama.2024.10341

Early Therapy for Symptomatic COPD, Asthma Improved Quality of Life

EmilyHarris

JAMA. 2024;332(2):97. doi:10.1001/jama.2024.10342

Review Calls for Standardized Long COVID Definition

EmilyHarris

JAMA. 2024;332(2):97. doi:10.1001/jama.2024.10343

Radiance

RonnieSirmans,ABJ

JAMA. 2024;332(2):174. doi:10.1001/jama.2024.7205

• Editor's Note

  Poetry and Seeing the Sacred in Medicine

  RafaelCampo,MD, MA

  JAMA

The Conquest of Yellow Fever

JAMA. 2024;332(2):175. doi:10.1001/jama.2023.18340

What Is Lynch Syndrome?

KaseyHornbuckle,MD; Cassandra D. L.Fritz,MD, MPHS

free access

JAMA. 2024;332(2):178. doi:10.1001/jama.2024.8552

This JAMA Patient Page describes Lynch syndrome, its risk factors and diagnosis, and its association with colorectal cancer and other specific cancers.

Coronary In-Stent Restenosis Treated With Pacl*taxel-Coated Balloon vs Uncoated Balloon

AllisonKratka,MD; Rita F.Redberg,MD, MSc

JAMA. 2024;332(2):169. doi:10.1001/jama.2024.9520

Coronary In-Stent Restenosis Treated With Pacl*taxel-Coated Balloon vs Uncoated Balloon—Reply

Robert W.Yeh,MD, MSc; Ajay J.Kirtane,MD, SM; AGENT IDE Investigators

JAMA. 2024;332(2):169-170. doi:10.1001/jama.2024.9523

Preoperative GLP-1 Receptor Agonists and Risk of Postoperative Respiratory Complications

David A.Milder,BMedMD, BSc; Tamara Y.Milder,MBBS, MMed; PeterKam,MBBS, MD

JAMA. 2024;332(2):170-171. doi:10.1001/jama.2024.10029

Preoperative GLP-1 Receptor Agonists and Risk of Postoperative Respiratory Complications

MarcLevi,MD

JAMA. 2024;332(2):171. doi:10.1001/jama.2024.10023

Preoperative GLP-1 Receptor Agonists and Risk of Postoperative Respiratory Complications

Ion A.Hobai,MD, PhD

JAMA. 2024;332(2):171-172. doi:10.1001/jama.2024.10026

Preoperative GLP-1 Receptor Agonists and Risk of Postoperative Respiratory Complications—Reply

Anjali A.Dixit,MD, MPH; Brian T.Bateman,MD, MS; Eric C.Sun,MD, PhD

JAMA. 2024;332(2):172-173. doi:10.1001/jama.2024.10032

Errors in Table 2

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JAMA. 2024;332(2):173. doi:10.1001/jama.2024.11152

Removal of Conflict of Interest Disclosure

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JAMA. 2024;332(2):173. doi:10.1001/jama.2024.11869

JAMA

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JAMA. 2024;332(2):89-90. doi:10.1001/jama.2023.18338